Research
Research Publications
Molecular Therapy — Nucleic Acids
Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice.
Krongbaramee T, Zhu M, Qian Q, Zhang Z, Eliason S, Shu Y, Qian F, Akkouch A, Su D, Amendt BA, Yang L, Hong L. Mol Ther Nucleic Acids. 2021 Feb 4;23:1204-1216. doi: 10.1016/j.omtn.2021.01.030. eCollection 2021 Mar 5. PMID: 33664998 Free PMC article.
The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.
Sweat M, Sweat Y, Yu W, Su D, Leonard RJ, Eliason SL, Amendt BA. Stem Cells. 2021 Feb 2. doi: 10.1002/stem.3342. Online ahead of print.PMID: 33529466
Gene-environment interaction in molar-incisor hypomineralization.
Bezamat M, Souza JF, Silva FMF, Corrêa EG, Fatturi AL, Brancher JA, Carvalho FM, Cavallari T, Bertolazo L, Machado-Souza C, Koruyucu M, Bayram M, Racic A, Harrison BM, Sweat YY, Letra A, Studen-Pavlovich D, Seymen F, Amendt B, Werneck RI, Costa MC, Modesto A, Vieira AR. PLoS One. 2021 Jan 6;16(1):e0241898. doi: 10.1371/journal.pone.0241898. eCollection 2021. PMID: 33406080 Free PMC article.
MicroRNA function in craniofacial bone formation, regeneration and repair.
Hong L, Sun H, Amendt BA. Bone. 2021 Mar;144:115789. doi: 10.1016/j.bone.2020.115789. Epub 2020 Dec 9. PMID: 33309989
Ectodermal Organ Development Is Regulated by a microRNA-26b-Lef-1-Wnt Signaling Axis.
Eliason S, Sharp T, Sweat M, Sweat YY, Amendt BA. Front Physiol. 2020 Jul 14;11:780. doi: 10.3389/fphys.2020.00780. eCollection 2020.PMID: 32760291 Free PMC article.
Child Neuropsychology In Press
Brain Structure and Neural Activity Related to Reading in Boys with Isolated Oral Clefts.
Conrad AL, Kuhlmann, Kuhlmann EH, van der Plas E, Axelson E
Child Neuropsychology. In Press. doi: 10.1080/09297049.2021.1879765.
The Cleft Palate-Craniofacial Journal
Retrospective Evaluation of Number of Surgeries and Parent Ratings of Academic and Behavioral Functioning Among Children With Isolated Oral Clefts.
Amy L. Conrad, Emily Kuhlmann and Canice E. Crerand
Cleft Palate Craniofac J. 2020 Dec 30:1055665620982807. doi: 10.1177/1055665620982807. Epub ahead of print. PMID: 33380226.
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
Lindsey Rhea and Martine Dunnwald
doi: 10.3791/61616 Published: August 21, 2020
The Cleft Palate Craniofacial Journal
Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model
Emily Hope Kuhlmann and Amy Lynn Conrad
Cleft Palate Craniofac J. 2020 Mar;57(3):310-320. doi: 10.1177/1055665619867015. Epub 2019 Aug 1. PMID: 31370691; PMCID: PMC6994360.
Journal of Dental Research July 2020
Sox2 Controls Periderm and Rugae Development to Inhibit Oral Adhesions
Sweat YY, Sweat M, Yu W, Sanz-Navarro M, Zhang L, Sun Z, Eliason S, Klein OD, Michon F, Chen Z, Amendt BA.
J Dent Res. 2020 Jul 17:22034520939013. doi: 10.1177/0022034520939013.
Frontiers in Physiology July 2020
Ectodermal Organ Development Is Regulated by a microRNA-26b-Lef-1-Wnt Signaling Axis.
Eliason S, Sharp T, Sweat M, Sweat YY, Amendt BA.
Frontiers in Physiology 2020 Jul 14;11:780. doi: 10.3389/fphys.2020.00780. eCollection 2020. PMID: 32760291 Free PMC article.
Pitx2-Sox2-Lef1 interactions specify progenitor oral/dental epithelial cell signaling centers.
Yu W, Sun Z, Sweat Y, Sweat M, Venugopalan SR, Eliason S, Cao H, Paine ML, Amendt BA
Development. 2020 Jun 4;147(11):dev186023. doi: 10.1242/dev.186023. PMID: 32439755
Preliminary evaluation of pre-speech and neurodevelopmental measures in 7-11-week-old infants with isolated oral clefts.
Amy L. Conrad, Kathleen Wermke, Michael Eisenmann, Emily Kuhlmann, Amanda Benavides, Timothy Koscik & Vincent Magnotta
Pediatr Res. 2020 Apr 12:10.1038/s41390-020-0887-5. doi: 10.1038/s41390-020-0887-5. Epub ahead of print. PMID: 32279071; PMCID: PMC7554202.
Human Gene Therapy November 2019
Enhancement of MicroRNA-200c on Osteogenic Differentiation and Bone Regeneration by Targeting Sox2-Mediated Wnt Signaling and Klf4
Akkouch A, Eliason S, Sweat ME, Romero-Bustillos M, Zhu M, Qian F, Amendt BA, Hong L.
Hum Gene Ther. 2019 Nov;30(11):1405-1418. doi: 10.1089/hum.2019.019. Epub 2019 Aug 16.
Developmental Biology November 2019
Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.
Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA.
Dev Biol. 2019 Nov 23. pii: S0012-1606(19)30492-0. doi: 10.1016/j.ydbio.2019.11.010. [Epub ahead of print]
Frontiers in Genetics September 2019
Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.
Gowans LJJ, Cameron-Christie S, Slayton RL, Busch T, Romero-Bustillos M, Eliason S, Sweat M, Sobreira N, Yu W, Kantaputra PN, Wohler E, Adeyemo WL, Lachke SA, Anand D, Campbell C, Drummond BK, Markie DM, van Vuuren WJ, van Vuuren LJ, Casamassimo PS, Ettinger R, Owais A, van Staden I, Amendt BA, Adeyemo AA, Murray JC, Robertson SP, Butali A.
Front Genet. 2019 Sep 20;10:800. doi: 10.3389/fgene.2019.00800. eCollection 2019.
Stem Cell Developmental August 2019
MicroRNA-200c Attenuates Periodontitis by Modulating Proinflammatory and Osteoclastogenic Mediators.
Akkouch A, Zhu M, Romero-Bustillos M, Eliason S, Qian F, Salem AK, Amendt BA, Hong L.
Stem Cells Dev. 2019 Aug 1;28(15):1026-1036. doi: 10.1089/scd.2019.0027. Epub 2019 May 20.
FoxO6 regulates Hippo signaling and growth of the craniofacial complex.
Sun Z, da Fontoura CSG, Moreno M, Holton NE, Sweat M, Sweat Y, Lee MK, Arbon J, Bidlack FB, Thedens DR, Nopoulos P, Cao H, Eliason S, Weinberg SM, Martin JF, Moreno-Uribe L, Amendt BA.
PLoS Genet. 2018 Oct 4;14(10):e1007675. doi: 10.1371/journal.pgen.1007675. eCollection 2018 Oct.
Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor.
Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F.
Development. 2018 Jan 8;145(1). pii: dev155929. doi: 10.1242/dev.155929.
Human Molecular Genetics, 2016 February
Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.
Liu H., Leslie E.J., Jia Z., Smith T., Eshete M., Butali A., Dunnwald M., Murray J., Cornell R.A. (2016) Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.
American Journal of Human Genetics 2016 April
A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3.
Leslie, E.J., Liu, H., Carlson, J.C., Shaffer, J.R., Feingold, E., Wehby, G., Laurie, C.A., Jain, D., Laurie, C.C., Doheny, K.F., McHenry, T., Resick, J., Sanchez, C., Jacobs, J., Emanuele, B., Vieira, A.R., Neiswanger, K., Standley, J., Czeizel, A.E., Deleyiannis, F., Christensen, K., Munger, R.G., Lie, R.T., Willcox, A., Romitti, P.A., Field, L.L., Padilla, C.D., Cutiongco-de la Paz, E.M.C., Lidral, A.C., Valencia-Ramirez, L.C., Lopez-Palacio, A.M., Valencia, D.R., Arcos-Burgos, M., Eduardo E. Castilla, E.E., Mereb, J.C., Poletta, F.A., Orioli, I.M., Carvalho, F.M., Hecht, J.T., Blanton, S.H., Buxó, C.J., Butali, A., Mossey, P.A., Adeyemo, W.L., James, O., Aregbesola, B.S., Mekonen A. Eshete, M.A., Gowans, L.J.J., Donkor, P., Koruyucu, M., Seymen, F., Ma, L., de Salamanca, J.E., Weinberg, S.M., Moreno, L., Cornell, R.A., Murray, J.C., Marazita, M.L. (2016) A genome-wide association study of nonsyndromic cleft palate identifies an etiologic missense variant in GRHL3. 98(4):744-54
Birth Defects Research Part A: Clinical and Molecular Teratology 2016 December
Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate.
Liu, H., Busch T., Eliason, S., Anand, D., Bullard, S., Gowans, L.J.J., Nidey, N., Saadi, I., Lachke, S.A., Zhu, Y., Adeyemo, A., Amendt, B., Roscioli, T., Cornell, R.A., Murray, J., Butali, A. (2016) Exome Sequencing Confirms the Role of ARHGAP29 in Mendelian Orofacial Clefting. Birth Defects Research Part A: Clinical and Molecular Teratology 2016 Dec 28. doi: 10.1002/bdra.23596. PubMed PMID: 28029220.
Nature Communications January 2017
Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
Liu, H., Leslie E.J., Carlson, J.C., Beaty, T.H., Marazita, M.L., Lidral, A.C., Cornell, R.A. (2017) Identification of common, non-coding variants at 1p22 that are pathogenic for non-syndromic orofacial clefting, Nature Communications 8:14759. doi: 10.1038/ncomms14759.
Journal of Dental Research 2017 September
Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate.
Eshete MA, Liu H, Li M, Adeyemo WL, Gowans LJJ, Mossey PA, Busch T, Deressa W, Donkor P, Olaitan PB, Aregbesola BS, Braimah RO, Oseni GO, Oginni F, Audu R, Onwuamah C, James O, Augustine-Akpan E, Rahman LA, Ogunlewe MO, Arthur FKN, Bello SA, Agbenorku P, Twumasi P, Abate F, Hailu T, Demissie Y, Hailu A, Plange-Rhule G, Obiri-Yeboah S, Dunnwald MM, Gravem PE, Marazita ML, Adeyemo AA, Murray JC, Cornell RA, Butali A. (2017) Loss-of-function GRHL3 variants detected in African patients with isolated cleft palate. J Dent Res. 2017 Sep 1:22034517729819. doi: 10.1177/0022034517729819
Developmental Dynamics 2017 November
Zebrafish models of orofacial clefts.
Duncan K, Mukherjee K, Cornell RA, Liao EC. (2017) Zebrafish models of orofacial clefts Dev Dyn. doi: 10.1002/dvdy.24566. Review.
Identification of Isthmin 1 as a Novel Clefting and Craniofacial Patterning Gene in Humans.
Lansdon LA, Darbro BW, Petrin AL, Hulstrand AM, Standley JM, Brouillette RB, Long A, Mansilla MA, Cornell RA, Murray JC, Houston DW, Manak JR. (2017) Identification of Isthmin1 as a novel clefting and craniofacial patterning gene in humans. Genetics. 2017 Nov 21. pii: genetics.300535.2017. doi: 10.1534/genetics.117.300535. PMID:29162626
Genetic Epidemiology 2017 December
Identification of 16q21 as a modifier of nonsyndromic orofacial cleft phenotypes.
Carlson JC, Standley J, Petrin A, Shaffer JR, Butali A, Buxó CJ, Castilla E, Christensen K, Deleyiannis FW, Hecht JT, Field LL, Garidkhuu A, Moreno Uribe LM, Nagato N, Orioli IM, Padilla C, Poletta F, Suzuki S, Vieira AR, Wehby GL, Weinberg SM, Beaty TH, Feingold E, Murray JC, Marazita ML, Leslie EJ. Genet Epidemiol. 2017 Dec;41(8):887-897. doi: 10.1002/gepi.22090. Epub 2017 Nov 10.
Molecular Genetics & Genomic Medicine 2017 September
Analysis of sequence data to identify potential risk variants for oral clefts in multiplex families.
Holzinger ER, Li Q, Parker MM, Hetmanski JB, Marazita ML, Mangold E, Ludwig KU, Taub MA, Begum F, Murray JC, Albacha-Hejazi H, Alqosayer K, Al-Souki G, Albasha Hejazi A, Scott AF, Beaty TH, Bailey-Wilson JE.Mol Genet Genomic Med. 2017 Aug 9;5(5):570-579. doi: 10.1002/mgg3.320. eCollection 2017 Sept. PMID: 28944239
Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios.
Haaland ØA, Jugessur A, Gjerdevik M, Romanowska J, Shi M, Beaty TH, Marazita ML, Murray JC, Wilcox AJ, Lie RT, Gjessing HK.PLoS One. 2017 Sep 12;12(9):e0184358. doi: 10.1371/journal.pone.0184358. eCollection 2017.PMID: 28898263
Journal of Dental Research 2017 August
The Use of Variant Maps to Explore Domain-Specific Mutations of FGFR1.
Lansdon LA, Bernabe HV, Nidey N, Standley J, Schnieders MJ, Murray JC1 J Dent Res. 2017 Oct;96(11):1339-1345. doi: 10.1177/0022034517726496. Epub 2017 Aug 21.
Journal of Dental Research 2017 October
ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions.
Paul BJ, Palmer K, Sharp JC, Pratt H, Murray SA, Dunnwald M. “Oral cleft patient-derived ARHGAP29 mutation causes lethality and oral adhesions in mice.” J Dent Res. 2017 Oct;96(11):1298-1305. doi: 10.1177/0022034517726079. Epub 2017 Aug 17.
Journal of Dental Research 2017 September
Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate.
Eshete MA, Liu H, Li M, Adeyemo WL, Gowans LJJ, Mossey PA, Busch T, Deressa W, Donkor P, Olaitan PB, Aregbesola BS, Braimah RO, Oseni GO, Oginni F, Audu R, Onwuamah C, James O, Augustine-Akpan E, Rahman LA, Ogunlewe MO, Arthur FKN, Bello SA, Agbenorku P, Twumasi P, Abate F, Hailu T, Demissie Y, Hailu A, Plange-Rhule G, Obiri-Yeboah S, Dunnwald MM, Gravem PE, Marazita ML, Adeyemo AA, Murray JC, Cornell RA, Butali A.J Dent Res. 2017 Sep 1:22034517729819. doi: 10.1177/0022034517729819.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2017 August
A comparative study of quality of life of families with children born with cleft lip and/or palate before and after surgical treatment.
Emeka CI, Adeyemo WL, Ladeinde AL, Butali A. J Korean Assoc Oral Maxillofac Surg. 2017 Aug;43(4):247-255. doi: 10.5125/jkaoms.2017.43.4.247. Epub 2017 Aug 24.
Cancer Cell International 2017 June
Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa.
Adeola HA, Soyele OO, Adefuye AO, Jimoh SA, Butali A. Cancer Cell Int. 2017 Jun 5;17:61. doi: 10.1186/s12935-017-0432-8. eCollection 2017. Review.
Molecular Genetics and Genomic Medicine 2017 March
The prevalence, penetrance, and expressivity of etiologic IRF6 variants in orofacial clefts patients from sub-Saharan Africa.
Gowans LJ, Busch TD, Mossey PA, Eshete MA, Adeyemo WL, Aregbesola B, Donkor P, Arthur FK, Agbenorku P, Olutayo J, Twumasi P, Braimah R, Oti AA, Plange-Rhule G, Obiri-Yeboah S, Abate F, Hoyte-Williams PE, Hailu T, Murray JC, Butali A. Mol Genet Genomic Med. 2017 Jan 12;5(2):164-171. doi: 10.1002/mgg3.273. eCollection 2017 Mar.
Annals of Maxillofacial Surgery 2016 July
Cleft lip and palate: Parental experiences of stigma, discrimination, and social/structural inequalities.
Adeyemo WL, James O, Butali A. Ann Maxillofac Surg. 2016 Jul-Dec;6(2):195-203. doi: 10.4103/2231-0746.200336.
Molecular Genetics and Genomic Medicine 2017 January
Genetics and genomics etiology of nonsyndromic orofacial clefts.
Adeyemo WL, Butali A. Mol Genet Genomic Med. 2017 Jan 17;5(1):3-7. doi: 10.1002/mgg3.272. eCollection.
Birth Defects Research 2017 January
Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate.
Liu H, Busch T, Eliason S, Anand D, Bullard S, Gowans LJJ, Nidey N, Petrin A, Augustine-Akpan EA, Saadi I, Dunnwald M, Lachke SA, Zhu Y, Adeyemo A, Amendt B, Roscioli T, Cornell R, Murray J, Butali A. Birth Defects Res. 2017 Jan 20;109(1):27-37. doi: 10.1002/bdra.23596.